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Citrus bioflavonoids

Citrus Bioflavonoids, Chinese plant extract manufacturer, professional importer and exporter

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Citrus Bioflavonoids and Diosmin: Synergistic Flavonoids for Vascular Health

Introduction

Citrus fruits are not only rich in vitamin C but also contain a diverse array of bioflavonoids that provide significant health benefits. Citrus bioflavonoids, including Hesperidin, naringin, and other flavonoid compounds, work synergistically with vitamin C and have demonstrated remarkable benefits for vascular health, circulation, and antioxidant protection. Diosmin, a semi-synthetic flavonoid derived from Hesperidin, is one of the most clinically validated flavonoid compounds for venous health, making both citrus bioflavonoids and Diosmin essential ingredients in the nutraceutical and pharmaceutical industries.

Product Introduction

Citrus Bioflavonoids are extracted from the fruit of Citrus aurantium using water and alcohol extraction. The extract appears as a light yellow-brown fine powder and is available in concentrations of 40%, 80%, and 90%, tested by HPLC.

Diosmin is produced from Citrus aurantium using pyridine extraction. It appears as a greyish-yellow or light yellow hygroscopic powder and is available in multiple pharmaceutical-grade specifications including 90% EP Micronized, 90% EP Granular, 9:1 Micronized, and 9:1 Granular. All products are tested by HPLC, with PAHs below 50ppb and BAP below 10ppb.

Efficacy and Mechanism of Action

Citrus bioflavonoids exert their health benefits through multiple complementary mechanisms. They are potent antioxidants that protect cells from oxidative damage, enhance the absorption and utilization of vitamin C, and strengthen capillary walls by reducing their permeability and fragility. These vascular protective effects are particularly beneficial for reducing bruising, supporting healthy circulation, and maintaining venous tone.

The anti-inflammatory properties of citrus bioflavonoids are mediated through the inhibition of pro-inflammatory enzymes and the modulation of signaling pathways involved in the inflammatory response. These compounds also exhibit anti-allergic properties by inhibiting histamine release from mast cells, making them useful for respiratory health and allergy management.

Diosmin, a flavone glycoside, is one of the most extensively studied flavonoids for venous health. Its primary mechanism of action involves increasing venous tone by prolonging the vasoconstrictor effect of norepinephrine on venous walls. Diosmin also reduces capillary permeability, improves lymphatic drainage, and protects microcirculation by inhibiting the adhesion and migration of leukocytes.

Clinical studies have consistently demonstrated the efficacy of diosmin in treating chronic venous insufficiency, reducing symptoms of leg heaviness, pain, and edema. The micronized form of diosmin has enhanced bioavailability, allowing for better absorption and more consistent therapeutic effects. Diosmin is often combined with Hesperidin in a 9:1 ratio (micronized purified flavonoid fraction or MPFF) for synergistic effects on venous and lymphatic function.

Application Fields

Citrus Bioflavonoids are widely used in the dietary supplement industry for vascular health, antioxidant support, and immune function formulations. They are available in capsules and tablets, often combined with vitamin C for enhanced bioavailability and synergistic effects.

Diosmin is primarily used in the pharmaceutical and nutraceutical industries for venous health formulations targeting chronic venous insufficiency, hemorrhoids, and lymphedema. It is available in tablet and capsule forms, with micronized formulations offering superior bioavailability. The cosmetics industry is also exploring citrus bioflavonoids for their anti-inflammatory and circulation-enhancing properties in skincare products targeting puffiness and dark circles.

For more information about our Citrus Bioflavonoids and Diosmin products, please contact Greensky Bio at www.greenskybio.com.