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home > FAQ > Plant Extract > P5P (Pyridoxal-5-Phosphate): Complete Guide to Benefits, Applications and Quality

P5P (Pyridoxal-5-Phosphate): Complete Guide to Benefits, Applications and Quality

2026-04-22

What is P5P (Pyridoxal-5-Phosphate)?

Pyridoxal-5-Phosphate (P5P) is the active, coenzyme form of Vitamin B6. Unlike the more common pyridoxine HCl, P5P is the biologically active form that the body can use directly without requiring conversion in the liver. This makes P5P particularly valuable for individuals with genetic variations (such as MTHFR mutations) that impair their ability to convert inactive B6 into its active form.

Key Benefits

  • Active Form: The bioactive form of Vitamin B6 that the body can use immediately, without requiring hepatic conversion.

  • Neurotransmitter Synthesis: Essential cofactor for producing serotonin, dopamine, GABA, and other critical neurotransmitters that regulate mood and cognitive function.

  • Homocysteine Metabolism: Works with folate and B12 to help maintain healthy homocysteine levels, supporting cardiovascular health.

  • Energy Production: Plays a vital role in amino acid metabolism and glycogen breakdown for energy.

  • Hormonal Balance: Supports healthy hormone regulation and may help with PMS symptoms.

Product Specifications

SpecificationDetails
Chemical NamePyridoxal-5-Phosphate Monohydrate (P5P)
CAS Number41468-25-1
Purity≥98% (HPLC)
Test MethodHPLC
AppearanceWhite to yellowish crystalline powder
SolubilitySparingly soluble in water
StorageStore in cool, dry place, away from light
Shelf Life24 months
Packaging1kg/drum or customized

Applications

  • Active B6 dietary supplements

  • Methylation support formulations

  • Mood and cognitive health products

  • Pharmaceutical formulations

Quality Standards

  • Manufactured in GMP-certified facility

  • Third-party lab tested for identity, potency, and purity

  • Free from heavy metals, pesticides, and microbial contamination

  • Compliant with USP, EP, and CP standards

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