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Grape Leaf Extract

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Grape Leaf Extract: Quercetin-3-O-Beta-D-Glucuronide for Vascular Health

Introduction

While grape seeds and skins are well known for their health benefits, grape leaves (Vitis vinifera L.) have also been recognized for their medicinal properties in traditional European medicine. Grape leaves contain unique bioactive compounds, particularly Quercetin-3-O-beta-D-glucuronide, that have demonstrated significant benefits for vascular health and microcirculation. Standardized Grape Leaf Extract is a valuable natural ingredient for circulatory health formulations.

Product Introduction

Grape Leaf Extract is produced from the leaves of Vitis vinifera L. using water and alcohol extraction. The extract appears as a brown fine powder and is standardized to 1% Quercetin-3-O-beta-D-Glucuronide, tested by TLC. Greensky Bio maintains strict quality control standards with PAHs below 50ppb and BAP below 10ppb.

Efficacy and Mechanism of Action

The primary bioactive compound in standardized Grape Leaf Extract is Quercetin-3-O-beta-D-glucuronide, a flavonol glycoside with potent vascular protective properties. This compound exerts its effects through multiple mechanisms that support venous and capillary health.

Quercetin-3-O-beta-D-glucuronide strengthens capillary walls and reduces capillary permeability, helping to prevent the leakage of fluid into surrounding tissues that contributes to edema and swelling. This venotonic effect is similar to that of other flavonoid-rich extracts used for venous health, but the specific glycoside form found in grape leaves may offer unique bioavailability advantages.

The compound also exhibits significant antioxidant activity, protecting endothelial cells from oxidative damage and supporting the structural integrity of blood vessels. Its anti-inflammatory properties further contribute to vascular health by reducing the expression of adhesion molecules and inflammatory mediators in the vascular endothelium.

Grape leaves also contain other beneficial compounds including flavonoids, phenolic acids, and tannins, which contribute to the overall health benefits of the extract. The traditional use of grape leaf preparations for heavy legs, varicose veins, and hemorrhoids is supported by the vascular protective properties of these compounds.

Application Fields

Grape Leaf Extract is used in the dietary supplement industry for venous health, leg circulation, and microcirculation support formulations. It is available in capsules and tablets, often combined with other circulatory-supportive ingredients such as horse chestnut extract, butcher's broom, and Diosmin.

The cosmetics industry incorporates grape leaf extract into products targeting tired, heavy legs and under-eye puffiness, leveraging its venotonic and anti-edema properties. The extract is also finding applications in functional foods and beverages targeting circulatory health.

For more information about our Grape Leaf Extract products and specifications, please contact Greensky Bio at www.greenskybio.com.